AI-Native Bioadaptive Neuromodulation

Therapy in dialogue with the nervous system.

The Ellipse™ platform fuses multi-modal physiologic sensing with embedded intelligence — estimating patient state in real time and adapting neural therapy continuously, so treatment follows the person, not a preset program.

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Investigational device — Not approved by the U.S. FDA
ECAP · ELECTROPHYSIOLOGY NIR REFLECTOMETRY · OPTICS PPG ×2 · HEMODYNAMICS ECG · ELECTROCARDIOGRAPHY MOTION · ACCELEROMETRY ADAPTIVE THERAPY
Sensor fusion → patient state estimation → adaptive dosing
0×Concurrent sensing modalities fused on-implant
0Physiologic parameters tracked longitudinally
24·7Continuous state estimation, in clinic and at home
US+INTLPatents issued & pending across the platform
The Platform Shift

From stimulator to platform.

Wavegate began by rebuilding spinal cord stimulation around a closed loop. That work produced something larger: a general architecture for bioadaptive electroceutical therapy.

Conventional neuromodulation is open-loop — a fixed program delivered to a moving, changing nervous system. Posture shifts the target. Physiology drifts. The dose a patient actually receives is not the dose that was set. Ellipse™ is engineered to close that gap, pairing continuous sensing at the neural interface with control laws designed to hold therapy on target through motion, position, and time.

Because the platform is built on sensing and state estimation rather than any single anatomy, it generalizes. The same optical front end, the same fusion engine, and the same adaptive control stack are designed to extend across the peripheral and autonomic nervous system — a foundation for expanding electroceutical indications well beyond chronic pain.

SENSE ESTIMATE ADAPT LEARN Wavegate Therapeutic Intelligence Engine™

Sense

Multi-modal signal acquisition at the neural interface — evoked potentials, optical reflectometry, hemodynamics, ECG, and motion, sampled continuously.

Estimate

An AI-enabled fusion engine converts raw datastreams into physiologic state — posture, activity, sleep, autonomic tone, and predicted pain.

Adapt

Hierarchical control regulates the therapeutic field in real time, with feedforward compensation designed to anticipate transient events before they perturb therapy.

Learn

Longitudinal data flows to a secure cloud, refining individual models over time and compounding platform intelligence with every patient-year.

Sensing Layer · StimuLux™

Electrophysiology anchors it.
Optics carry it.

At the core of Ellipse™ is hybrid ECAP-anchored optical reflectometry: near-infrared optics track the geometry of the neural target continuously, while evoked compound action potentials provide periodic electrophysiologic ground truth — keeping the optical channel calibrated to the tissue it serves.

SignalSourceRole in the loop
ECAP Stimulation electrode array Electrophysiologic anchor — periodic ground truth of neural recruitment
NIR REFLECTOMETRY StimuLux™ optical lead Continuous tracking of target geometry through posture and motion
CSF HYDRODYNAMICS Derived from NIR reflectometry Craniospinal-compliance / cerebrovascular-reactivity monitoring, relative ICP trend, and Valsalva event detection
PPG ×2 Anatomically distinct optical sites Hemodynamics, O₂ saturation, and regional vs. peripheral autonomic tone
MOTION 3-axis implant accelerometry Posture classification, activity, and feedforward event prediction
CARDIORESP ECG/PPG Heart rate, variability, respiration, BP trending, and blood flow — autonomic context for state estimation
// All channels time-aligned on-implant and streamed to the fusion engine
Intelligence Layer

From signals to state.

Raw waveforms are not the product — understanding is. Ellipse™ fuses its sensor streams into a live estimate of the patient state.

Synthetic Pain Index

A continuously computed, physiology-derived correlate of reported pain — designed to give clinicians an objective longitudinal signal between visits.

Sympathetic Index

Regional and peripheral autonomic tone estimated from anatomically exclusive optical sources — a window into the stress physiology that shapes chronic pain.

Feedforward prediction

Motion signatures are detected as they begin, so stimulation is designed to adapt ahead of the event rather than after it.

Fleet learning

De-identified longitudinal data is designed to refine estimation models across the platform — the system improves with every patient-year.

EMonitoring · Ellipse™ Longitudinal Physiology
SYNCED 05:16
Sleep CycleLight
Heart Rate52 bpm
Resp. Rate12 br/m
Synthetic Pain Index1.1 /10
Patient NRS/VAS0.7 /10
O₂ Saturation97.1 %
SLEEPstage
HRbpm
PAIN0–10
O₂ SAT%
8/7 07:008/7 19:008/8 07:008/8 19:00latest

Regional Sympathetic Index

IDENTIFIED
NIRv vaso0.441
May vaso0.334
HR chrono0.560
RMSSD chrono0.398
RSI = σ( 0.44·z_NIRv + 0.33·z_May
      + 0.56·z_HR + 0.40·z_RMSSD )
Ellipse™ Clinician Programmer · simulated data
Investigational software — not FDA approved
The System

An instrument built around its sensors.

Every element of the Ellipse™ implantable system — form, header, front end, and power — is engineered in service of one goal: uninterrupted, high-fidelity dialogue with the nervous system.

Ellipse™ implantable pulse generator — superellipse titanium housing with integrated optical header
/01

Superellipse form

A pebble-inspired geometry engineered to minimize surface contact pressure at the pocket — comfort as a design constraint, not an afterthought.

/02

Integrated optical header

Plug-and-play optical and electrical connectivity for StimuLux™-enabled leads — no specialized setup workflow required.

/03

Hybrid sensing front end

A shared analog front end acquires optical and electrophysiologic channels within implant-grade power budgets.

/04

Endurance by design

Advanced-chemistry cell, ultra-low-power silicon, and fast recharge through a ceramic-composite case.

/05

Guided clinical software

An iPadOS Clinician Programmer walks every workflow — trialing, implant, calibration, monitoring, maintenance, and MRI mode.

Indication Expansion

One platform. An expanding map of the nervous system.

Electroceutical medicine advances indication by indication — but the hard problems of sensing, state estimation, and adaptive control are shared. Ellipse™ is built to carry them across programs.

ProgramFocusStage
Chronic painLead program
Closed-loop SCS therapy with continuum-regulated dosing — the platform's proving ground.
Peripheral nerveExpansion
Targeted PNS therapies built on the same sensing and control stack.
Dorsal root ganglionExpansion
Focal therapy concepts.
Autonomic & cardiovascularResearch
Sympathetic-index-guided sensing for autonomically mediated indications.
ResearchPreclinicalClinicalMarket

All programs are investigational. No Wavegate device has been approved by the U.S. FDA or any regulatory authority, and none is available for sale.

Wavegate Corporation

Founded by clinicians.
Engineered for what's next.

Wavegate was founded on a simple conviction: neural therapy should answer to the patient in front of it.

Our physician-led team spans implantable systems engineering, photonics, control theory, machine learning, and regulatory science — with US and international patents issued and pending across the platform. We work with clinicians, researchers, and partners who share our view for the future of neuromodulation.

Investor & partnering inquiries Email us
Emailinfo@wavegate.us
Phone+1 337 419 1360
HQ4310 Ryan Street, Suite 107
Lake Charles, LA 70605
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